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    20MG/TAB * 30TAB

    Tamoxifen competitively binds to estrogen receptors on tumors and other tissue targets, producing a nuclear complex that decreases DNA synthesis and inhibits estrogen effects; nonsteroidal agent with potent antiestrogenic properties which compete with estrogen for binding sites in breast and other tissues; cells accumulate in the G0 and G1 phases; therefore, tamoxifen is cytostatic rather than cytocidal.

    Well absorbed.

    Hepatic; via CYP2D6 to 4-hydroxytamoxifen and via CYP3A4/5 to N-desmethyl-tamoxifen. Each is then further metabolized into endoxifen (4-hydroxy-tamoxifen via CYP3A4/5 and N-desmethyl-tamoxifen via CYP2D6); both 4-hydroxy-tamoxifen and endoxifen are 30- to 100-fold more potent than tamoxifen.

    Time to Peak
    Serum: ~5 hours.

    Half-Life Elimination
    Tamoxifen: ~5 to 7 days; N-desmethyl tamoxifen: ~14 days

    Detection Time
    ~60 days.

    • Manufacturer:AstraZeneca Pharmaceuticals

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