Daiichi Sankyo Pharmaceuticals

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EVISTA
60MG/TAB * 28TAB

Pharmacology
Raloxifene is an estrogen agonist/antagonist (a selective estrogen receptor modulator [SERM]); selective binding activates estrogenic pathways in some tissues and antagonizes estrogenic pathways in other tissues. Raloxifene acts like an estrogen agonist in the bone to prevent bone loss and has estrogen antagonist activity to block some estrogen effects in the breast and uterine tissues. Raloxifene decreases bone resorption, increasing bone mineral density and decreasing fracture incidence.

Absorption
Rapid; ~60%


Metabolism
Hepatic, extensive first-pass metabolism; metabolized to glucuronide conjugates.


Half-Life Elimination
27.7 hours (following a single dose); 32.5 hours (following multiple doses).

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