AstraZeneca Pharmaceuticals

Sort By:  
Click image to see product details
$50.00
Click image to see product details
$25.00
ARIMIDEX
1MG/TAB * 28TAB

Pharmacology
Anastrozole is a potent and selective nonsteroidal aromatase inhibitor. By inhibiting aromatase, the conversion of androstenedione to estrone, and testosterone to estradiol, is prevented, thereby decreasing tumor mass or delaying progression in patients with tumors responsive to hormones. Anastrozole causes an 85% decrease in estrone sulfate levels.

Absorption
Well absorbed; extent of absorption not affected by food.

Metabolism
Extensively hepatic (~85%) via N-dealkylation, hydroxylation, and glucuronidation; primary metabolite (triazole) inactive.

Time to Peak
Plasma: ~2 hours without food; 5 hours with food.

Half-Life Elimination
~50 hours.

Detection Time
~14 days.


Click image to see product details
$50.00
NOLVADEX-D
20MG/TAB * 30TAB

Pharmacology
Tamoxifen competitively binds to estrogen receptors on tumors and other tissue targets, producing a nuclear complex that decreases DNA synthesis and inhibits estrogen effects; nonsteroidal agent with potent antiestrogenic properties which compete with estrogen for binding sites in breast and other tissues; cells accumulate in the G0 and G1 phases; therefore, tamoxifen is cytostatic rather than cytocidal.

Absorption
Well absorbed.


Metabolism
Hepatic; via CYP2D6 to 4-hydroxytamoxifen and via CYP3A4/5 to N-desmethyl-tamoxifen. Each is then further metabolized into endoxifen (4-hydroxy-tamoxifen via CYP3A4/5 and N-desmethyl-tamoxifen via CYP2D6); both 4-hydroxy-tamoxifen and endoxifen are 30- to 100-fold more potent than tamoxifen.


Time to Peak
Serum: ~5 hours.


Half-Life Elimination
Tamoxifen: ~5 to 7 days; N-desmethyl tamoxifen: ~14 days


Detection Time
~60 days.

Click image to see product details
$25.00
Per Page      1 - 2 of 2
  • 1