Novartis Pharmaceuticals

Sort By:  
Click image to see product details
$70.00
FEMARA
2,5MG/TAB * 30TAB


Pharmacology
Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system which binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgens to estrogens (specifically, androstenedione to estrone and testosterone to estradiol). This leads to inhibition of the enzyme and a significant reduction in plasma estrogen (estrone, estradiol and estrone sulfate) levels. Does not affect synthesis of adrenal or thyroid hormones, aldosterone, or androgens.

Absorption
Rapid and well absorbed; not affected by food.

Metabolism
Hepatic via CYP3A4 and 2A6 to an inactive carbinol metabolite.

Time to Peak
Steady state, plasma: 2 to 6 weeks; steady state serum concentrations are 1.5 to 2 times higher than single-dose values.

Half-Life Elimination
Terminal: ~2 days.

Detection Time
~14 days.


Click image to see product details
$70.00
Per Page      1 - 1 of 1
  • 1